Recent Publications


Fortin, D.L., Nemani, V.M., Voglmaier, S.M., Anthony, M.D., Ryan, T.A., Edwards, R.H. 2005. Neural activity controls the synaptic accumulation of a-synuclein. J. Neurosci. 25, 10913-10921.


Li, H., Waites, C.L., Staal, R.G., Dobryy, Y., Park, J., Sulzer, D.L. Edwards, R.H. 2005. Sorting of vesicular monoamine transporter 2 to the regulated secretory pathway confers the somatodendritic exocytosis of monoamines. Neuron 48, 619-633.


Voglmaier, S.M., Kam, K., Yang, H., Fortin, D.L., Hua, Z., Nicoll, R.A., Edwards, R.H. 2006. Distinct endocytic pathways control the rate and extent of synaptic vesicle recycling. Neuron 51, 71-84.


Edwards, R.H. 2007. The neurotransmitter cycle and quantal size.   Neuron 55, 835-858.


Seal, R.P., Akil, O., Yi, E., Weber, C.M., Grant, L., Yoo, J., Clause, A., Kandler, K., Noebels, J.L., Glowatzki, E., Lustig, L.R., Edwards, R.H. 2008. Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3. Neuron 57, 263-275.


Nakamura, K., Nemani, V.M., Kaehlcke, K., Ott, M. and Edwards, R.H. 2008. Optical reporters for the conformation of a-synuclein reveal a specific interaction with mitochondria. J. Neurosci.28, 12305-12317.


Seal, R.P., Wang, X., Guan, Y., Raja, S.N., Woodbury, C.J., Basbaum, A.I. and Edwards, R.H. 2009. Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors. Nature 462, 651-655.


Nemani, V.M., Lu, W., Berge, V., Nakamura, K., Onoa, B., Lee, M.K., Chaudhry, F.A., Nicoll, R.A. and Edwards, R.H. 2010. Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis. Neuron 65, 66-79.


Hnasko, T.S., Chuhma, N., Zhang, H., Goh, G.A., Sulzer, D., Palmiter, R.D., Rayport, S. and Edwards, R.H. 2010. Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo. Neuron 65, 643-656.


Onoa, B., Li, H., Gagnon-Bartsch, J.A., Laura A.B. Elias and Edwards, R.H. 2010. Vesicular monoamine and glutamate transporters select distinct synaptic vesicle recycling pathways. J. Neurosci. 30, 7917-7927.


Stuber, G.D., Hnasko, T., Britt, J.P., Edwards, R.H. and Bonci, A. 2010. Dopaminergic terminals in the nucleus accumbens but not the dorsal striatum co-release glutamate. J. Neurosci. 30, 8229-8233.


Asensio, C.A., Sirkis, D.W., Edwards, R.H. 2010. RNAi screen identifies a role for adaptor protein AP-3 in sorting to the regulated secretory pathway. J. Cell Biol. 191, 1173-1187.


Nakamura, K., Nemani, V.M., Azarbal, F., Skibinski, G., Levy, J.M., Egami, K., Munishkina, L., Zhang, J., Gardner, B., Wakabayashi, J. et al. 2011. Direct membrane association drives mitochondrial fission by the Parkinson Disease-associated protein alpha-synuclein. J. Biol. Chem. (paper of the week), 286, 20710-20726.


Hua, Z., Leal-Ortiz, S., Foss, S.M., Waites, C.L., Garner, C.C., Voglmaier, S.,M., Edwards, R.H. 2011.   v-SNARE composition distinguishes synaptic vesicle pools. Neuron 71, 474-487.


Goh, G.,Y. Huang, H., Ullman, J., Borre, L., Hnasko, T.S., Trussell, L.O. and Edwards, R.H. 2011. Presynaptic regulation of quantal size: K+/H+ exchange stimulates glutamate storage by increasing membrane potential. Nat. Neurosci. 14, 1285-1292.


Hnasko, T.S., Hjelmsted, G.O., Fields, H.L., Edwards, R.H. 2012. Ventral tegmental area glutamate neurons: electrophysiological properties and projections. J. Neurosci. 32, 15076-85.


Sirkis, D.W., Edwards, R.H., Asensio, C.S. 2013. Widespread dysregulation of peptide hormone release in mice lacking adaptor protein AP-3. PloS Genetics 9, e1003812.


Foss, S.M., Li, H., Santos, M.S., Edwards, R.H., and Voglmaier, S.M. (2013). Multiple dileucine-like motifs direct vglut1 trafficking. J. Neurosci. 33, 10647-10660.


Asensio, C.S., Sirkis, D.W., Maas, J., Egami, K., To, T.-L., Brodsky, F.M., Shu, X., Cheng, Y., Edwards, R.H. (2013) Self-assembly of VPS41 promotes sorting required for biogenesis of the regulated secretory pathway. Dev. Cell. 27, 425-437.


Li, H., Fertuzinhos, S., Mohns, E., Hnasko, T.S., Verhage, M., Edwards, R., Sestan, N., and Crair, M.C. (2013). Laminar and columnar development of barrel cortex relies on thalamocortical neurotransmission. Neuron 79, 970-986.


Incontro, S., Asensio, C.S., Edwards, R.H., and Nicoll, R.A. (2014). Efficient, complete deletion of synaptic proteins using crispr. Neuron 83, 1051-1057.


Herring, B.E., Silm, K., Edwards, R.H., Nicoll, R.A. (2015). Is aspartate an excitatory neurotransmitter? J. Neurosci. 35, 10168-10171.


Pathak, D,. Shields, L., Mendelsohn, B.A., Haddad, D., Lin, W., Gerencser, A.A., Kim, H., Brand, M.D., Edwards, R.H., Nakamura, K. (2015). The role of mitochondrially derived ATP in synaptic vesicle recycling. J. Biol. Chem. (paper of the week), epub ahead of print.


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